Kourami: graph-guided assembly for novel human leukocyte antigen allele discovery
نویسندگان
چکیده
منابع مشابه
P-145: Role of Human Leukocyte Antigen in Miscarriage
Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The human leucocyte antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
متن کاملP-164: Human Leukocyte Antigen Class Ib and Pregnancy Success
Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
متن کاملSpecific "intra-allele" and "intra-broad antigen" human leukocyte antigen alloantibodies in kidney graft transplantation.
Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with one previous transplantation 15 years previously. In post-transplantation monito...
متن کاملAllele and haplotype frequencies at human leukocyte antigen class I and II genes in Venezuela's population.
Population studies represent an integral part and link in understanding the complex chain of host-pathogen interactions, disease pathogenesis, and MHC gene polymorphisms. Genes of Mongoloid, Caucasoid, and Negroid populations have created a distinctive HLA genetic profile in the Venezuelan population. Our objective was to determine the predominant HLA class I and II alleles and haplotype freque...
متن کاملNew human leukocyte antigen risk allele in Japanese patients with Takayasu arteritis.
BACKGROUND The association of human leukocyte antigen (HLA) alleles and Takayasu arteritis (TA) is not fully understood. The aim of the present study was to investigate HLA alleles in Japanese patients with TA and the association of these alleles with clinical manifestations. METHODS AND RESULTS A total of 96 patients diagnosed with TA according to the Guideline for Management of Vasculitis S...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2018
ISSN: 1474-760X
DOI: 10.1186/s13059-018-1388-2